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promyelocytic (M3) acute leukaemia; several individuals Convey an unusual morphologic spectrum intermediate amongst M2 and M3 AML.
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large charge of normal or dystrophic promyelocytes in peripheralblood As well as in bone marrow; no intracytoplasmic Auer rods; myeloperoxydasereaction good; immunocytochemical detection having an anti-PLZF exhibits adistinct punctate nuclear distribution of the protein, suggesting itscompartmentalization while in the nucleus.
Speedy detection of prognostically significant fusion transcripts in acute leukemia employing simplified multiplex reverse transcription polymerase chain response.
ZBTB16-RARα variant of acute promyelocytic leukemia with tuberculosis: a scenario report and review of literature.
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Prosperous allogeneic bone marrow transplantation in a situation of variant acute promyelocytic leukemia with ZBTB16-RARA.
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A situation of acute promyelocytic leukaemia with abnormal cytological characteristics plus a ZBTB16-RARA fusion gene.
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Characterization of cryptic rearrangements and variant translocations in acute promyelocytic leukemia.
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the translocation will involve a breakpoint while in the zinc fingerregion of PLZF, with fusion of two zinc fingers for the RARa B location toform a 5 PLZF - three RARa fusion gene; the reciprocal five RARa - 3 PLZF genefuses 7 zinc fingers towards the RARa location; RARas breakpoint occurs in1- on account of thealternative splicing of PLZF gene, two kinds of PLZF-RARa protein may be detected: